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By G. R. Stephenson, J.-P. Genet (auth.), G. R. Stephenson (eds.)

Asymmetric synthesis is without doubt one of the most important strategic matters in natural chemistry, and this booklet describes complicated suggestions and their purposes to the economic and laboratory synthesis of significant chiral molecules. The foreign staff of hugely revered authors supply rigorous and concise stories in their components of expertise.

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Noyori and M. Kitamura, Angew. , 1991, 103, 34; Angew. Chem. Int . Ed. , 1991,30, 49; (c) R. Noyori, S. Suga, K. Kawai, S. Okada, M. Kitamu ra, M. Ogun i, M. Hayashi, T. Kaneko and Y. Mat suda , J. Organomet. , 1990, 382, 19. 5. K. Soai and S. Niwa, Chem. , 1992,92, 833 (review). 6. e. Bo1m, G. Schlingloff and K. Harm s, Chem. , 1992, 125, 1191. 7. F. Biesemeier, PhD thesis, University of Marburg, 1993. 8. e. Bolm, 1. Muller, G. Schlingloff, M. Zehnder and M. Neuburger, J. Chem. , Chem. , 1993, 182.

Another attractive feature of this method is that it leads to good optical yields of products even when the reactions are performed at O°C. A related chiral binaphthyl catalyst has been introduced by Carreira et al. 40 Like the former method, low temperatures are not required for maximal ee and so again this method should be commercially significant. 05 eq) (R) solvent. O°C or -20°C. 30. I. ' -Q Bu-t N~ 0' : '.... ~ Et20. _lOoC. 4 h; 2. n-Bu4NF. THF R= Me~\ (97% ee), Ph~\ 0 OH II I MeO~ R (97% eel.

9). 2). : 28 I. 20 I Ti(O-i-Prl2Br2 (I mol%). 4A sieve~ 2. 2 Catalysed enantioselective glyoxylate-ene reaction'? 3 Effect of catalyst" concentration on enantioselective amplification-? 9 88 " BINO L/ TiCI2 (O·i· P rh (31% eel was used as chiral catalyst. Molecular weight (MW) measurements indicated the dimeric nature of both the homo- and heterochiral titanium complexesobtained from enantiopure and racemic BINOL, respectively. However, the dimers differ in stability. Whereas the homochiral one shows a concentration-dependent molecular weight, indicating its lability and high tendency to dissociate into catalytically active monomers, the heterochiral dimer exhibits no MW change over a wide concentration range.

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